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Stem Cells In Regenerative Medicine

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Stem Cells In Regenerative Medicine


$152.00

STEM CELLS IN REGENERATIVE MEDICINE: CARPE DIEM – CARPE VITAM

(ISBN 978-1-83859-011-6)

It also highlights important aspects of manufacturing and culturing of cell therapy products and administration of different types of stem cells in various systemic disorders.

Mike K.S. Chan & Dmitry Klokol
ISBN 978 1838590 116

 

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STEM CELLS IN REGENERATIVE MEDICINE: CARPE DIEM – CARPE VITAM

(ISBN 978-1-83859-011-6)

It also highlights important aspects of manufacturing and culturing of cell therapy products and administration of different types of stem cells in various systemic disorders.

Mike K.S. Chan & Dmitry Klokol
ISBN 978 1838590 116

In most of the doctors’ perception the term ‘regenerative medicine’ is associated with tissue reconstruction after severe injuries, burns or trauma. And that is absolutely correct except the fact that tissues and organs deteriorate and lose their function not only due to mechanical or physical damage, but as a result of chronic diseases, inflammation, age-related degeneration as well as genetic abnormalities and cellular dysfunction. The profound understanding of tissue morphology on the cellular level and studying of the ontogenesis open magnificent opportunities to restoration of structural and functional integrity of human organism.

Throughout centuries scientists and healthcare practitioners were in a constant pursuit of longevity—from Avicenna and Paracelsus to Brown-Sequad, Serge Voronoff and Paul Niehans. Not so long ago, in 1990’s, when the term regenerative medicine was tailored by Dr. Leland Kaiser and propagated by William Haseltine it was considered to be a medicine of the Future, «a new branch of medicine will develop that attempts to change the course of chronic disease and in many instances will regenerate tired and failing organ systems», as Dr. Leland Kaiser described it. A new hope spurred up that almost any condition can be at least improved if not cured by means of regenerative medicine, including those cases where conventional medicine is powerless or ineffective.

The Future Dr. Kaiser was talking about is certainly a Present today. Though relatively small amount of practitioners are aware of today’s regenerative medicine capabilities and many still consider it more like science fiction.

This book reveals concepts and protocols of successful approach to regenerative medicine by means of stem cell therapy. It also highlights important aspects of manufacturing and culturing of cell therapy products and administration of different types of stem cells in various systemic disorders.

Table of Content

Foreword xv
Introduction xix
PART 1 1
Chapter 1 3
UNDERSTANDING STEM CELLS 3
From Embryology to Regenerative medicine 3
History of stem cell research 6
Stem cell biology 15
Choice of Stem Cells in Wellness and Biological medicine 29
Chapter 2 33
PREPARATION, STANDARTIZATION, LABORATORY ANIMAL CARE, SAFETY PROTOCOLS, AND REGULATORY ASPECTS OF STEM CELLS, XENOTRANSPLANTS, AND BIOMOLECULAR THERAPY PRODUCTS 33
Animal sources of stem cell xenotransplants 36
Tissue procurement and cell culturing 41
Archiving of medical records and specimens from animal source 44
Quality control 45
Release and labelling of precursor stem cells 47
Chapter 3 51
GENETIC AND IMMUNOLOGICAL ASPECTS OF CELLULAR XENOTRANSPLANTATION 51
Genotype-phenotype distinction and relationships between donor cells and recipient 52
Epigenetics and Stem cells 57
Immunology and genetics in Stem cell therapy 61
Chapter 4 83
SAFETY CONSIDERATIONS OF FETAL XENOGENEIC PRECURSOR STEM CELLS 83
Chapter 5 109
STEM CELLS’ BIOCHEMICAL BASIS AND MECHANISMS OF ACTION 109
Homing and migration of fetal precursor stem cells 110
Adhesion, binding and interaction of fetal precursor stem cells 112
Paracrine mechanisms of fetal precursor stem cells 115
Soluble paracrine factors of fetal precursor stem cells 117
Insoluble paracrine factors of fetal precursor stem cells 118
Further considerations on immunogenicity of Fetal Precursor Stem Cells 122
Chapter 6 122
AUTOLOGOUS STEM CELLS AND ITS THERAPEUTIC POTENTIAL 127
Autologous stem cells and history of its transplantation 128
Autologous Stem Cell Transplantation 132
Very small embryonic stem cells (VSELs) 136
Clinical applications of Autologous SC transplantation in different diseases 147
PART 2 169
Chapter 7 171
MORPHO-PHYSIOLOGIC BACKGROUND AND SUBSTANTIATION OF PRECURSOR STEM CELL THERAPY USE IN NEURODEGENERATIVE DISEASES 171
Chapter 8 185
CELL THERAPY IN MANAGEMENT OF AUTISM SPECTRUM DISORDERS 185
Outlook on the etiology and pathogenesis of ASD. Role of genetics and immunity in development of Autism and ASD 186
Role of imaging studies and biological markers in Autism and ASD and its links to symptomatology 188
Integrative therapeutic protocol for Autism and ASD 191
Chapter 9 203
CELL THERAPY IN MANAGEMENT OF AUTISM SPECTRUM DISORDERS 203
Social and general medical aspects of AD 203
Therapeutic strategies in AD 218
Stem cell therapy in treatment of AD 225
Mito Organelles™ CNS Neuropeptides in management of AD 228
Chapter 10 233
CELL THERAPY IN PARKINSON’S DISEASE 233
Social and general medical aspects PD 233
Protective factors against PD 240
The role of mitochondria in PD 243
Clinical forms of PD 246
Clinical diagnosis of PD 252
Treatment strategies in PD 253
Treatment of Parkinson’s disease with precursor stem cells 257
Neuropeptides Mito Organelles™ CNS in management of PD 265
Transcranial electric and magnetic stimulation of the brain (TCS) 266
Chapter 11 271
CELL THERAPY IN STROKE MANAGEMENT 271
Social and general medical aspects of stroke 271
Risk factors and symptoms of stroke 277
Post-stroke rehabilitation 286
Stem cells and cell therapy in management of stroke 292
MO CNS neuropeptides in management of stroke patients 297
PART 3 303
Chapter 12 305
CELL THERAPY IN MANAGEMENT OF DIABETES MELLITUS 305
Morpho-physiology of pancreas and general medical aspects of diabetes mellitus 305
Stem cells and live cell therapeutic approach in management of diabetic patients 323
Chapter 13 335
CELL THERAPY IN MANAGEMENT OF CARDIOMYOPATHY 335
Pathogenesis of cardiomyopathies and cardiac regenerative potentials 335
Cell therapy as treatment modality in cardiomyopathy 359
Chapter 14 371
CELL THERAPY IN MANAGEMENT OF CHRONIC KIDNEY DISEASE 371
Mechanisms of kidney regeneration 372
Stem cells in kidney’s regeneration 372
Stem cells xenotransplantation in management of CKD 377
Chapter 15 389
CELL THERAPY IN MANAGEMENT OF LIVER DISEASE 389
Pathogenesis of liver disease 389
Cell therapy based treatment of liver disease 402
Chapter 16 421
CELL THERAPY IN TREATMENT OF MUSCULAR DYSTROPHIES 421
General medical considerations on muscular dystrophies 421
Pathogenesis and diagnostics of Muscular Dystrophy 424
Novel treatment strategies in Muscular Dystrophy 428
Chapter 17 439
CELL THERAPY IN MANAGEMENT OF RETINOPATHY 439
Retina’s morphology and pathogenesis of retinopathies 439
General considerations of cell therapy based treatment strategies in retinopathy 445
Bioengineering in Clinical Trials using Human Pluripotent Stem Cells 446
Precursor Stem Cell/ Live Cell Therapy in Retinal Diseases 452
Cell-based therapies for retinal pigment epithelium replacement 468
Cell-based therapies for photoreceptor replacement 471
Chapter 18 475
PLACENTAL THERAPY AS PART OF CELL THERAPY AND REGENERATIVE MEDICINE 475
Morphophysiology of placenta and physiological background of placental therapy 475
Main characteristics of placental therapy products 479
Biological and medicinal properties of placental extracts 483
Placental therapy in treatment of hair loss 486

Additional information

Weight 1 kg
Languages

English, Simplified Chinese, Transitional Chinese, Arabic

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