A Compilation of Cellular and Tissue Xenotransplantation Studies (1838-2022)
A Promising Approach for the Treatment of Diseases
- Additional information
The success of transplantation to treat human diseases has greatly increased the demand for organs and tissues. Xenotransplantation, the use of animals as donors, is viewed increasingly as a solution to this problem. The pig-to-NHP model has become the standard for preclinical studies of cell and tissue xenotransplantation prior to starting a clinical trial.
This is A Compilation of Cell and Tissue Xenotransplantation Studies (1838-2022): A Promising Approach for the Treatment of Diseases and a collection of reminiscences by surgeons and scientists who made significant research contributions toward achieving successful transplantation of animal cells and tissues into humans. It records the works of the world’s leading researchers in this field which will impact the future medical care of patients with diabetes, liver failure, neurodegenerative disorders, corneal blindness, etc.
It also provides a comprehensive overview of applications of cellular and tissue xenotransplantation for a range of diseases especially those that result from tissue loss or dysfunction. The importance of the decellularization technique in animal tissues and organs as implantable biomaterials in the field of regenerative medicine and tissue engineering is also highlighted.
Essential reading for physicians, scientists, and lay persons with an interest in xenotransplantation; those caring for patients with life-threatening diseases; and also those interested in understanding the potential of genetic and tissue engineering in science and medicine. This book charts a historical record of the research which has contributed to the advancement of medicine called “the next great medical revolution.” Many believe we are on the threshold of clinical trials using genetically modified animals as organ donors. If successful, the benefits of clinical xenotransplantation will be enormous and will represent one of the greatest advances in modern medicine.
By Prof Dr Mike KS Chan, Prof. Dr. Michelle B.F. Wong, Dr Patricia Pan, Yvonne Chia, Clarice EA, Yee Hui Rong and Yenny Kenisi
Published by EUROPEAN WELLNESS ACADEMY – Medical Research: ISBN: 9781662930041, eISBN: 9781662928574
Library of Congress Control Number: 2022941169
Professor Dato’ Sri Dr. Mike K.S. Chan is a pioneer of Cellular and Cell Membrane Therapy in Europe and Asia since the early 1980’s. He founded one of the world’s largest researchers of Bio-Molecular Medicine based in Switzerland and Germany with a global presence in almost eighty countries. He has conducted more than 1,000 lectures, seminars, and symposiums worldwide in the fields of antiaging, cell regeneration, regenerative medicine, and stem-cell therapies.
𝗙𝗢𝗟𝗟𝗢𝗪 𝗣𝗥𝗢𝗙. 𝗗𝗔𝗧𝗢’ 𝗦𝗥𝗜 𝗗𝗥. 𝗠𝗜𝗞𝗘 𝗖𝗛𝗔𝗡:
Prof. Dato’ Sri Dr. Michelle Wong Bi Fah, ND, PhD, is a scientist actively involved in research and development (R&D) work on stem cells focusing on Foetal Precursor Stem-Cell Therapy. She is the Co-Founder/Technical Advisor and Researcher of FCTI Inc. Her primary role is envisioning and devising a strategic roadmap for the organization’s growth, especially in today’s rapidly evolving business ecosystem. A prominent speaker, Dr. Wong presents at educational programs and global conferences on cell therapy and biological medicine for physicians and healthcare practitioners worldwide.
Dr. Patricia Pan is a researcher specializing in the fields of animal stem cells, clinical microbiology, environmental microbiology, and medical biotechnology and immunology. She holds a PhD in Biotechnology focusing on natural immunomodulators which augment the immune system to protect against infections. Dr. Pan lectured and trained medical laboratory technology students as a tutor, lecturer, and Head of School in the field of Medical Laboratory Technology. Lecture topics included clinical microbiology, immunology and serology, immunohematology and clinical parasitology. Mentored students achieved successful careers as medical laboratory technologists. She currently works as the Head of Research focusing on developing new research projects including protocol design, analysis, and results interpretation. She is also a prolific contributing writer of review and research articles in the field of regenerative medicine including stem cells biology, its mechanisms, and medical application. Dr. Pan currently monitors the progress of preclinical animal studies and clinical trials for Investigational New Drug (IND) submission.
MED121000 MEDICAL / Regenerative Medicine
MED044000 MEDICAL / Immunology
MED106000 MEDICAL / Research
Table of Content
|CELLULAR AND TISSUE XENOTRANSPLANTATION AS A POTENTIAL THERAPY||11|
|PRECLINICAL ANIMAL STUDIES IN CELLULAR AND TISSUE XENOTRANSPLANTATION||15|
|COLLECTION OF CELLULAR AND TISSUE XENOTRANSPLANTATION STUDIES||24|
|CELLULAR AND TISSUE XENOTRANSPLANTATION FOR THE TREATMENT OF DISEASES AND DISORDERS||29|
|Islet Xenotransplantation for the Treatment of Type I Diabetes||29|
|Hepatocyte Xenotransplantation for Liver Failure||24|
|Neuronal Cell Xenotransplantation for the Treatment of Neurodegenerative Disorders||37|
|Corneal Xenotransplantation for the Treatment of Corneal Blindness||42|
|CELLULAR AND TISSUE XENOTRANSPLANTATION FOR TISSUE REGENERATION||46|
|Xenogeneic Mesenchymal Stem Cells for Tissue Regeneration||46|
|Skin Xenografts as Skin Substitutes in Burn Treatment||52|
|Decellularized Xenogeneic Tissues and Organs as Implantable Biomaterials
in Regenerative Medicine and Tissue Engineering
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